SSKI
Since potassium iodide is highly soluble in water, a saturated solution of potassium iodide, abbreviated SSKI, contains 1 gram (1000 mg) KI per milliliter (mL) of solution. This is less than 100% by weight, because SSKI is significantly more dense than pure water. Because KI is about 76.4% iodide by weight, SSKI contains about 764 mg iodide per mL, which is usually rounded to 750 mg/mL for convenience (50 mg iodide per drop, at 15 drops per mL typical of viscous liquids like SSKI).
Saturated solutions of potassium iodide can be an emergency treatment for hyperthyroidism (so-called thyroid storm), as high amounts of iodide temporarily suppress secretion of thyroxine from the thyroid gland.[citation needed] The dose typically begins with a loading dose, then 1/3 mL (5 drops = 250 mg iodide) SSKI, three times per day.
Iodide solutions made from a few drops of SSKI added to drinks have also been used as expectorants to increase the water content of respiratory secretions and encourage effective coughing.[citation needed]
SSKI may be used in radioiodine-contamination emergencies (i.e., nuclear accidents) to "block" the thyroid's uptake of radioiodine (this is not the same as blocking the thyroid's release of thyroid hormone). The dose is smaller: 130 mg KI per day (100 mg iodide) which represents 2 drops of SSKI solution per day, for an adult.
SSKI has been proposed as a topical treatment for sporotrichosis, but no trials have been conducted to determine the efficacy or side effects of such treatment. [9]
[edit] Radiation protection
Following the Chernobyl nuclear reactor disaster in April, 1986, a saturated solution of potassium iodide (SSKI) was administered to 10.5 million children and 7 million adults in Poland[10] as a prophylactic measure against accumulation of radioactive iodine-131 in the thyroid gland.
Potassium iodide was also approved in 1982 by the US FDA to protect the thyroid glands from radioactive iodine. In the event of an accident or attack at a nuclear power plant, or fallout from a nuclear bomb, several volatile fission product radionuclides may be released. 131I is a common fission by-product and is particularly dangerous as the body concentrates it in the thyroid gland, which may lead to thyroid cancer. By saturating the body with a source of stable iodide prior to exposure, inhaled or ingested 131I tends to be excreted. Potassium iodide cannot protect against any other causes of radiation poisoning, nor can it provide any degree of protection against dirty bombs that produce radionuclides other than isotopes of iodine.
Recommended Dosage for Radiological Emergencies involving radioactive iodine[11] Age KI in mg
Over 12 years old 130
3 – 12 years old 65
1 – 36 months old 32
< 1 month old 16
See fission products and the external links for more details.
Potassium iodide’s (KI) value as a radiation protective (thyroid blocking) agent was demonstrated at the time of the Chernobyl nuclear accident when Soviet authorities distributed it in a 30 km zone around the plant. The purpose was to protect residents from radioactive iodine, a highly carcinogenic material found in nuclear reactors which had been released by the damaged reactor. Only a limited amount of KI was available, but those who received it were protected. Later, the US Nuclear Regulatory Commission (NRC) reported, “thousands of measurements of I-131 (radioactive iodine) activity…suggest that the observed levels were lower than would have been expected had this prophylactic measure not been taken. The use of KI…was credited with permissible iodine content in 97% of the evacuees tested.” [12]
Poland, 300 miles from Chernobyl, also distributed KI to protect its population. Approximately 18 million doses were distributed, with follow-up studies showing no known thyroid cancer among KI recipients. [13] With the passage of time, people living in irradiated areas where KI was not available have developed thyroid cancer at epidemic levels, which is why the US Food and Drug Administration (FDA) reported “The data clearly demonstrate the risks of thyroid radiation…KI can be used [to] provide safe and effective protection against thyroid cancer caused by irradiation. [14]
Chernobyl also demonstrated that the need to protect the thyroid from radiation was greater than expected. Within ten years of the accident, it became clear that thyroid damage caused by released radioactive iodine was virtually the only adverse health effect that could be measured. As reported by the NRC, studies after the accident showed that “As of 1996, except for thyroid cancer, there has been no confirmed increase in the rates of other cancers, including leukemia, among the…public, that have been attributed to releases from the accident.” [15]
But equally important to the question of KI is the fact that radiation releases are not “local” events. Researchers at the World Health Organization accurately located and counted the cancer victims from Chernobyl and were startled to find that “the increase in incidence [of thyroid cancer] has been documented up to 500 km from the accident site…significant doses from radioactive iodine can occur hundreds of kilometers from the site, beyond emergency planning zones." [16] Consequently, far more people than anticipated were affected by the radiation, which caused the United Nations to report in 2002 that “The number of people with thyroid cancer…has exceeded expectations. Over 11,000 cases have already been reported.” [17]
These findings were consistent with studies of the effects of previous radiation releases. In 1945, millions of Japanese were exposed to radiation from nuclear weapons, and the effects can still be measured. Today, nearly half (44.8%) the survivors of Nagasaki studied have identifiable thyroid disease, with the American Medical Association reporting “it is remarkable that a biological effect from a single brief environmental exposure nearly 60 years in the past is still present and can be detected.” [18]
These events, as well as the development of thyroid cancer among residents in the North Pacific from radioactive fallout following the United States' nuclear weapons testing in the 1950’s (on islands nearly 200 miles downwind of the tests) were instrumental in the decision by the FDA in 1978 to issue a request for the availability of KI for thyroid protection in the event of a release from a commercial nuclear power plant or weapons-related nuclear incident. Noting that KI’s effectiveness was “virtually complete” and finding that iodine in the form of potassium iodide (KI) was substantially superior to other forms including iodate (KIO3) in terms of safety, effectiveness, lack of side effects, and speed of onset, the FDA invited manufacturers to submit applications to produce and market KI. [19] Today, three companies (Anbex, Inc., Fleming Co, and Recip of Sweden) have met the strict FDA requirements for manufacturing and testing of KI, and they offer products (IOSAT, ThyroShield, and Thyro-Safe, respectively) which are available for purchase.
More here http://en.wikipedia.org/wiki/Potassium_iodide
Even more.
http://www.ki4u.com/
